The Effect of Nitroprusside on the Renal Ischaemia-reperfusion Injury
نویسنده
چکیده
Nitric oxide (NO) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. In the kidney, NO is involved in haemodynamic regulation, control of vascular tone and tubular function. Formation of oxygen-derived free radicals (OFR) have been documented in renal ischaemiareperfusion before. In this study, we investigated the significance of NO formation, by the addition of nitroprusside (0.2 mm) as an NO donor, in the ischaemiareperfused (IR) kidneys. Induction of IR significantly reduced renal function compared to controls. In this study, nitroprusside showed beneficial effects on renal morphology although did not alter renal function over a short period of time. Acta Medica Iranica 40(1): 60-64; 2002
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